Formulation and Evaluation of Poly Herbal Formulation against CCl4 Induced Hepatotoxicity

Aegle marmelos L, Eclipta alba L. and Phyllanthus amarus are well known herbs as hepatoprotective agents. The preventive effects of polyherbal formulation containing the above herbs were evaluated against carbon tetra chloride (CCl4) induced hepatotoxicity in rats. CCl4 induced fatty degeneration and vacuole formation and significantly increased the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in rat s plasma. Treatment with the herbal formulation significantly decreased the levels of AST and ALT in plasma. Also histopathological studies showed that the formulation reduced the incidence of liver lesions induced by CCl4. The study proved that the formulation prepared from A. marmelos, P. amarus and E. alba may be used in the treatment of CCl4 induced hepatotoxicity.