Author/Authors :
Ashok Kumar, B.S Sri K.V.College of Pharmacy - Department of Pharmacognosy, India , Saran, G. Sri K.V.College of Pharmacy - Department of Pharmacognosy, India , Bharath, K.N. Sri K.V.College of Pharmacy - Department of Pharmacognosy, India , Manoj, B. Sri K.V. College of Pharmacy - Department of Pharmaceutical Chemistry, India , Kulashekar, K.S Sri K.V.College of Pharmacy - Department of Pharmacology, India
Abstract :
Alstonia scholaris Linn. is traditionally used to treat constipation. The present study was carried to investigate laxative activity of aqueous extract of A. scholaris on albino Wistar rats. Rats were divided in to 4 groups of 6 animals each, first group as control, second group served as standard (Senna-30 mg/kg), while group 3 and 4 were treated with aqueous extract of A. scholaris at doses of 100 and 200 mg/kg body weight (p.o.), respectively. The laxative activity was determined based on the weight of feces matter. The aqueous extract of the plant produced significant (p 0.01) laxative activity at both doses. The results showed that the aqueous extract of A. scholaris has a significant laxative activity and supports its traditional use in herbal medicine
