Author/Authors :
Jameel, Ghassan H. J College of Veterinary Medicine - University of Diyala, Diyala , Iraq , Mohammed, Zahid I. College of Veterinary Medicine - University of Diyala, Diyala , Iraq , Taher, Maisaa G. College of Medicine - University of Diyala, Diyala, Iraq , Bahloul, AudyHisham Department of Scientific Affairs - University of Diyala, Iraq , Taha Lateef, Sufyan Department of Scientific Affairs - University of Diyala, Iraq
Abstract :
Ivermectin drug used in the treatment of endo and ecto parasites in animals, but in this study was used
to treat Bovine ocularsquamous cell carcinoma (BOSCC) at a dose 200 mg /Kg body weight. Forty cattle were
used in this study in a period from January 2014 to December 2015. The result of this study was revealed significant
increase (P≤0.05) in the mean of total white blood cells count (5.39 ± 1.052) cell/mm3
before treatment and reach to
(6.49 ± 0.422)cell/mm3
after treatment and the mean of lymphocyte rate (34.5 ± 3.20)% before treatment and reach
to (60.6±10.83)% after treatment. Also, there was significant depression (P≤0.05) in the means of neutrophils and
monocytes rates (59.4 ±4.52)% , (4.3 ±1.40)% before treatment compare with percentage of cells after treatment were
(34.4 ±9.56)% , (2.2 ± 1.15)% respectively. The result showed significant (P≤0.05) decreased in the TNF-Alpha level
(10.1 ± 1.1) ng/L in after treatment, while was (14.9 ± 0.48) ng/L before treatment compare with the control group
was (6.5 ± 3.1) ng/L. Sixteen cattle were recovering from sum of twenty cattle in the treated group, the cure rate
reaches to 80% with sign of loss the cancer mass size without any side effect on the animals. The Ivermectin could be
a drug to treat BOSCC with a 80% cure rate.
