Production of Neomycin Using Immobilized Cells of Streptomyces Marinensis NUV-5

S. marinensis NUV-5 cells were immobilized in various matrices like, glass wool, polyurethane foam, absorbent cotton, cotton cloth, granular carbon and granular pumice stone. Among various support matrices, glass wool, polyurethane foam, absorbent cotton were found to be better, while cotton cloth, granular carbon and granular pumice were found to be poor support matrices for whole cell immobilization as well as antibiotic production. The repeated batch fermentations of the shaken flasks, a good level of antibiotic was maintained for a period of 24 days using immobilized cells on polyurethane foam and glass wool.