THE POTENTIAL OF INTERSTITIAL STEM CELLS FOR CORRECTING LIVER AND KIDNEYS DYSFUNCTION IN RABBITS AFTER COPPER TOXICATION

Copper accumulates in tissues until reaching the toxic level, at which time pathological changes then develop. The belief is that the genetic defects are responsible for disease and copper toxicosis is a cause rather than the result of tissue disease but it is not the primary cause. The tissue alterations, vacoulation, degeneration and necrosis, decreased after stopping copper toxication and the organs excrete the excess copper by certain ways. This clearance enhances the interstitial stem cells or their precursors to incorporate in regeneration of the lost tissue mass . Moreover, to some extents, the bone marrow stem cells may introduce some plasticity to regenerate some of this lost tissue mass. The present experiment was designed using the local rabbit Oryctolagus cuniculus. The animals were sacrificed during and after toxication period as well as after non-toxication periods. The results support the opinion that the interstitial stem cells or even bone marrow stem cells are incorporated into regeneration of the lost tissues after toxication and clearance