Author/Authors :
Banaee, Touka mashhad university of medical sciences - Khatam al-Anbia Eye Hospital - Ophthalmic Research Center, مشهد, ايران , Abrishami, Majid mashhad university of medical sciences - Khatam al-Anbia Eye Hospital - Ophthalmic Research Center, مشهد, ايران , Daneshvar-Kakhki, Ramin mashhad university of medical sciences - Khatam al-Anbia Eye Hospital - Ophthalmic Research Center, مشهد, ايران , Zarei-Ghanavati, Siamak mashhad university of medical sciences - Khatam al-Anbia Eye Hospital - Ophthalmic Research Center, مشهد, ايران , Mahmoudi, Mahmoud mashhad university of medical sciences - mmunology Research Center, مشهد, ايران
Abstract :
Purpose: Chlamydia pneumonia is a known endothelial pathogen in several vascular diseases including atherosclerosis, age-related macular degeneration and non-arteritic anterior ischemic optic neuropathy. Diabetic retinopathy is a retinal vascular disease that may similarly be affected. We serologically investigated the presence of C. pneumonia infection in patients with proliferative diabetic retinopathy. Design: Pilot case-control study. Patients Methods: During a period of 12 months, we examined sera of 27 type I diabetic patients with different stages of diabetic retinopathy for anti-chlamydial IgG and IgA by enzyme-linked immunosorbent assay (ELISA). Results: The IgG seropositivity was significantly different between different diabetic retinopathy groups (P=0.017). Rate of seropositivity was higher among patients with PDR comparing to patients without PDR, with a marginal significance (P=0.062). Although the titer of IgA was negative in all patients (less than 0.357 U/mL), the IgA titer was higher in patients with PDR than those without PDR, reaching the significance at P 0.06 level. Conclusion: C. pneumonia may be an independent risk factor for proliferative diabetic retinopathy.
Keywords :
Chlamydia Pneumonia , Diabetic Retinopathy , Serology , Diabetes Mellitus
