Author/Authors :
Mirshahi, Ahmad tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Dezhagah, Habib tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Lashay, AliReza tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Tabatabaei, Ali tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Farahvash, Mohammad-Sadegh tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Faghihi, Hooshang tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Abdollahi, Ali tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Karkhaneh, Reza tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Movasat, Morteza tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Riazi-Esfahani, Mohammad tehran university of medical sciences tums - Farabi HospitaL - Eye Research Center, تهران, ايران , Nili-Ahmad Abadi, Mehdi tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Aalami-Harandi, Zahra tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Javadian, Ahmad tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Mansouri, Mohammad-Reza tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Vakili, Davood tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Piri, Niloufar tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران , Roohipour, Ramak tehran university of medical sciences tums - Farabi Eye Hospital - Eye Research Center, تهران, ايران
Abstract :
Purpose: To compare the success rate of adjunctive 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH), and daunomycin in combination with triamcinolone during vitrectomy in eyes with retinal detachment (RD) and proliferative vitreoretinopathy (PVR).Methods: In this prospective randomized clinical trial, 69 eyes from 69 patients with RD and PVR (grade B or C) randomized to 3 groups. Group 1: received 5-FU and LMWH (200 microgram/ml 5-FU and 5 IU/ml LMWH, Fragmin); group 2: received daunomycin (0.5 mg) in 500 cc infusion fluid; and group 3: control group. In all patients, 0.1 cc intravitreal triamcinolone was used during vitrectomy. The patients visited on day 1, week 1, month 1, 3 and 6. Best corrected visual acuity (BCVA) and retinal status compared in the 3 groups.Results: Complete data were available for 60 out of 69 patients. Thirty five patients (58.3%) were male and 25 patients (41.7%) were female. The patient age range was 19-84 years and the mean age was 49. The groups did not have significant difference in age, sex, duration of detachment, severity of PVR, preoperative visual acuity (V/A), lens status, type of tamponade and encircling band and buckle. Postoperative V/A and retina status also was the same in the 3 groups.Conclusion: Perioperative infusion of 5-FU, LMWH and daunomycin does not significantly increase the success rate of patients with RD and PVR comparing to control group. Although visual acuity improvement and retina reattachment rate in group 1 and 2 were better than control group, but statistical analysis failed to show significant difference between the 3 groups
