Author/Authors :
Fitri Hendrawan, Viski Faculty of Veterinary Medicine Brawijaya University, Puncak Dieng Eksklusif, Kalisongo, Dau Sub-districts, Malang Districts , Sadda Cakrawati, Liza Faculty of Veterinary Medicine Brawijaya University, Puncak Dieng Eksklusif, Kalisongo, Dau Sub-districts, Malang Districts , Aulanni’am, Aulanni’am Faculty of Veterinary Medicine Brawijaya University, Puncak Dieng Eksklusif, Kalisongo, Dau Sub-districts, Malang Districts , Wulansari, Desi Faculty of Veterinary Medicine Brawijaya University, Puncak Dieng Eksklusif, Kalisongo, Dau Sub-districts, Malang Districts , Oktanella, Yudit Faculty of Veterinary Medicine Brawijaya University, Puncak Dieng Eksklusif, Kalisongo, Dau Sub-districts, Malang Districts , Chandra Agustina, Galuh Faculty of Veterinary Medicine Brawijaya University, Puncak Dieng Eksklusif, Kalisongo, Dau Sub-districts, Malang Districts
Abstract :
There is an increase population growth in Indonesia. Therefore, it is necessary to control this through the
use of antifertility agents. Both cepoka eggplant (Solanum torvum S.) and Kapok seeds (Ceiba pentandra G.) have a role
as antifertility agents as contains solasodine and gossypol compounds respectively. This study aims to determine the
difference between the effect of cepoka eggplant extract and Kapok seed as male antifertility agents on the expression
of p53 protein in the seminiferous tubular tissue and the number of Leydig cells in rats. A total of 18 male Wistar
rats, 2.5-3 months old and 190-320 g weight were randomly divided into 3 groups with 6 replicats, as follows: the
negative control group (K-) without treatment, group 1 (G1) given 1 g/kg Cepoka eggplant extract, and group 2 (G2)
admistered 0.1 g/kg Kapok seed extract. The results showed that the administration of 0.1 g/kg Kapok seed extract
(Ceiba pentandra G.) significantly increased the expression of p53 protein and reduced the number of Leydig cells
compared with the administration of 1 g/kg Cepoka eggplant extract (Solanum torvum S.). It was concluded that
Kapok seed extract can be used as antifertility agent as increase the expressions of p53 protein and reduce the number
of Leydig cells.
Keywords :
Cepoka Eggplant , Kapok Seed , Antifertility Agent , Protein p53 , Leydig Cells
