Author/Authors :
Gu, Yeun-Hwa Department of Radiological Science - Faculty of Health Science - Junshin Gakuen University - Fukuoka, Japan , Yamashita, Takenori Department of Radiological Science - Faculty of Health Science - Suzuka University of Medical Science - Mie, Japan , Yamamoto, Hajime Department of Geneinformatics - Graduate School of Pharmaceutical Sciences - Nagoya City University - Nagoya, Japan , Matsuo, Tatsuhiko Validux Co., Ltd., 5-1-5 Imaike - Chikusa-Ku - 464-0850 Nagoya, Japan , Washino, Noriyuki Research Institute for Ishokudogen - 9-14-3 Kanbe - Suzuka-City - 513-0801 Mie Pref., Japan , Song, Jin-Ho Department of Radiation Oncology - Seoul St. Mary’s Hospital - College of Medicine - The Catholic University of Korea - Seoul - Republic of Korea , Kang, Ki-Mun Department of Radiation Oncology - Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital - Changwon - Republic of Korea
Abstract :
Increased caloric intake and Westernized dietary choices may be contributing toward a recent rising trend of incidences of chronic
lifestyle-related diseases. In this study, we evaluated the anticancer properties of Plant Enzyme Validux (PEV) using a mouse model.
Five-week-old male C3H mice were randomly distributed into four experimental groups: Control, PEV only, 6Gy irradiation only,
and PEV + 6Gy. PEV was orally administered daily at 500 mg/kg for 14 days prior to three rounds of 2Gy irradiation. We focused
on the anticancer action and immunostimulatory efects of PEV with and without irradiation. Oncogene suppression was observed
afer PEV treatment as was an increase in TNF-�, suggesting an antitumor efect. PEV administration also appeared to reduce
oxidative stress as evidenced by a decrease in lipid peroxidation. In addition, PEV confrmed radioprotective efect by radical
blocking ability by radiation irradiation. Immunological responses to PEV administration were evidenced by an increase in number
of total white blood cells and T lymphocytes. Immunotherapy is drawing more and more attention as a treatment for prostate
cancer, suggesting that there will be a need for the identifcation of specifc targets for prostate cancer and for more basic research
on the genetic aspects of immunotherapy.Tus, PEV may be of use as a radioprotective supplement during radiotherapy for tumor treatment.
Keywords :
Plant Enzymes , Decrease Prostate Cancer Cell Numbers , Increase TNF- In Vivo , Immunostimulatory Activity , Increased caloric
