Author/Authors :
abodola, ma alneelain university - faculty of medicine and health sciences - department of pharmacology, Sudan , lutfi, mf alneelain university - faculty of medicine and health sciences - department of physiology, Sudan , lutfi, mf qassim university - college of medicine, Saudi Arabia , bakhiet, ao university of science and technology - deanship of scientific research, Sudan , mohamed, ah national center of research - medicinal and aromatic plant research institute - department of pharmacology, Sudan
Abstract :
Background: Prosopis chilensis is used locally in Sudan for inflammatory conditions of joints; however, literature lacks scientific evidence for anti-inflammatory effect of this plant. Aims: To evaluate anti-inflammatory and analgesic effects of prosopis chilenses. Material and Methods: Edema inhibition percent (EI %) and hot plate method were used to evaluate anti-inflammatory and analgesic effects of Prosopis chilenses in Wistar albino rats. Anti-inflammatory and analgesic effects of Prosopis chilenses were compared to indomethacin and acetylsalicylic acid respectively. Results: Ethanolic extract of prosopis chilensis at a dose of 200and 100mg/kg body weight achieved peak EI% (EI% = 96.1%) and (EI% = 94.4%) three and four hours after oral dosing respectively. The maximum EI% for indomethacin was 97.0% and was recorded after 4 hours following oral administration of the drug at a dose of 5 mg/kg body weight. Prosopis chilensis extracts at doses of 100 and 200 mg/kg body weight significantly increased the rats’ response time to hot plate compared to acetylsalicylic acid at a dose rate of 100mg/kg body weight (P 0.05). Conclusion: The current results suggest potential anti-inflammatory and analgesic effects of prosopis chilenses. Relevance of these effects to prosopis chilenses phy-to-constituents was discussed.
Keywords :
analgesic , anti , inflammatory , prosopis chilenses
