Anti-inflammatory Effects of Pioglitazone in Diabetic Kidney Transplant Recipients

The adverse effects of oxidative stress and inflammation on kidney transplants have been shown by investigational studies in animal models and a number of controlled clinical trials. Oxidative stress plays a major role in the pathogenesis of systemic inflammation. Chronic inflammation at 1 and 5 years after transplantation is related to the higher rates of graft loss and lower kidney function. Inflammation and oxidative stress are the most important reasons of cardiovascular morbidity and mortality in patients with chronic kidney disease.