Author/Authors :
Anis, Sabiha Sindh Institute of Urology and Transplantation (SIUT) - Dewan Farooq Medical Centre (DFMC) - Department of Molecular Biology and Immunology, Pakistan , Kumar, Rajesh Sindh Institute of Urology and Transplantation (SIUT) - Dewan Farooq Medical Centre (DFMC) - Department of Hepatogastroenterology, Pakistan , Abbas, Zaigham Sindh Institute of Urology and Transplantation (SIUT) - Dewan Farooq Medical Centre (DFMC) - Department of Hepatogastroenterology, Pakistan , Hassan, Syed Mujahid Sindh Institute of Urology and Transplantation (SIUT) - Dewan Farooq Medical Centre (DFMC) - Department of Hepatogastroenterology, Pakistan , Luck, Nasir Hassan Sindh Institute of Urology and Transplantation (SIUT) - Dewan Farooq Medical Centre (DFMC) - Department of Hepatogastroenterology, Pakistan , Muzaffar, Rana Sindh Institute of Urology and Transplantation (SIUT) - Dewan Farooq Medical Centre (DFMC) - Department of Molecular Biology and Immunology, Pakistan
Abstract :
Coeliac disease (CD) often coexists with other autoimmune and primary immunodeficiency diseases (PID), creating a problem in timely diagnosis and management. An unusual case of coeliac disease that was difficult to diagnose and manage because of its unusual clinical presentation. Initiallydiagnosed as celiac disease but showed poor response to standard therapy is reported. Frequent attacks of opportunistic infections led to immunodeficiency work-up that revealed natural killer cell (NK) deficiency with low serum IgA and IgG2 levels. The patient eventually succumbed to recurrent infections. The co-existence of PID is unusual in a patient with CD. Thiscase report highlights the importance of investigating PID in patients with autoimmunity.
