Title of article :
Clomiphene-acetyl cysteine combination as a new protocol to a friendly IVF cycle
Author/Authors :
Rizk, Ahmed Y Benha University - Assiut School of Medicine - Departments of Obstetrics and Gynecology, Egypt , Bedaiwy, Mohamed A Benha University - Assiut School of Medicine - Department of Obstet and Gynecol, Egypt , Al- Inany, Hesham G. Cairo University - Department of Obstet and Gynecol, Egypt
Abstract :
Objective: N-acetyl-cysteine (NAC) has been shown to enhance the action of clomiphene citrate in ovulation induction.The objective of this study was to examine the use of NAC with clomiphene citrate for ovarian stimulation inassisted conception as a model for Friendly IVFDesign: pilot study Materials and methods: Twenty infertile patients undergoing IVF/ICSI cycles were offered NAC, 1,200 mg/day fromday 3-7 of the menstrual cycle with CC (100 mg /day) starting on day 3-7. hCG (10,000 IU) was given when leadingfollicle(s) were . 18mm followed by ICSI.Main outcome measure(s): clinical pregnancy rate was the primary outcome and implantation rate, number of oocytes retrieved, fertilization rate were secondary outcomes Result(s): response to CC stimulation with NAC co-treatment was evident by a number of mature follicles ranging from 2-7 at the time of hCG administration. Clinical pregnancy was achieved in 4 cycles (20%).Conclusion(s): In this preliminary report, a potential benefit of NAC co-treatment with CC in young women undergoing IVF/ICSI cycles was demonstrated. This combination provides a cheap, effective way for ovulation induction in an IVF setting compatible with the concept of friendly IVF
Keywords :
N , acetyl , cysteine , clomiphene citrate, Friendly IVF, ICSI, pregnancy
Journal title :
Middle East Fertility Society Journal
Journal title :
Middle East Fertility Society Journal