Author/Authors :
oguntoye, olubunmi s. university of kwazulu-natal - school of chemistry and physics - natural products research group, South Africa , oguntoye, olubunmi s. university of ilorin - faculty of physical sciences - department of chemistry, bioorganic chemistry research group, Nigeria , hamid, abdulmumeen a. university of ilorin - faculty of physical sciences - department of chemistry, bioorganic chemistry research group, Nigeria , iloka, gabriel s. university of ilorin - faculty of physical sciences - department of chemistry, bioorganic chemistry research group, Nigeria , bodede, sunday o. university of kwazulu-natal - school of chemistry and physics - natural products research group, South Africa , owalude, samson o. university of ilorin - faculty of physical sciences - department of chemistry, bioorganic chemistry research group, Nigeria , tella, adedibu c. university of ilorin - faculty of physical sciences - department of chemistry, bioorganic chemistry research group, Nigeria
Abstract :
A series of new Schiff bases of Imesatin and Isatin derivatives which have been previously prepared from the reaction of Hydrazine monohydrate, p-phenylenediamine and 4,4- diaminodiphenylmethane with Isatin were reported. The compounds were characterized by elemental analyses, UV-visible, Infrared and Nuclear Magnetic Resonance (1H NMR and 13C NMR) spectroscopic analyses. The synthesized Schiff bases were obtained in moderate to excellent yields between 55.3 – 89.3%. Infrared spectra of all synthesized compounds contain the characteristic azomethine linkage (-CH=N) between 1580 – 1630 cm^-1 and the N–H of the Isatin ring signals between δ 8.32 – 10.68 ppm in their 1H NMR spectra. The present work affords reaction pathway that is efficient and operational simplicity for the synthesis of Schiff bases derivatives.
Keywords :
Schiff bases , isatin , imesatin , spectroscopic analysis , biological activity
