Synthesis and Characterization of4-(4-bromophanyl)-s-phenyl- 1,2,3- ThiadiazolesAs a Biological Active Compounds

4, 5-diaryl- 1,2,3-thiadiazoles show biological activities. They have been as an giotensin II antagonists, PPAR(alpha)agonists, antimicrobial and antitumor agents, anticonvulsants, antiinflammatory agents, insecticides and fungicides.In this study 4-(4- bromophenyl)-5-phenyl-1,2,3-thiadiazole was synthesized by two methods and the results were compared. In the first method, bromophenyl was used as a starting material but in the other method, bromination reaction was used in the final step for a bromo substitution. Results have shown that the first step had higher yield and fewer steps. These synthesizes were confirmed by wet elemental analysis, IR and 1H NMR spectroscopies