STUDY ON HLA-DQB1 *03 ALLELE ASSOCIATED WITH WOMEN HUMAN PAPILLOMA VIRUS HPV) LESIONS

Objectives: The specific HLA alleles associated with HPV differ among various study groups. It has been suggested that women carrying HLA-DQw3 antigen encoded by DQB 1*03, are predisposed to develop cervical cancer. The aim of this study was to determine HLA-DQB1*03 alleles in HPV lesions. Methodology: In a cross-sectional and analytical study, Hundred women enrolled into the study. Twenty of them had abnormal Pap smear, Fifty patients had condyloma lesions and 30 patients with malignant lesions. HLA–DQB*03 and HPV infection was evaluated by PCR. Results: PCR of HPV was positive in 50 women with condyloma lesions and 8 women with malignant lesion (p 0.001). HLA–DQB*03 was positive in 9 women with abnormal Pap smear , 18 women with condyloma lesions and 7 women with malignant lesion(P= 0.261). Positive PCR of HPV was significantly higher in women with condyloma lesions than other women (p 0.001). Mean age of patients with positive PCR of HPV was significantly lower than patients with negative PCR of HPV (P= 0.001). Mean age of patients with positive HLA–DQB*03 was 42.08 + 11.48 year and mean age of patients with negative HLA–DQB*03 Was 43.83 +11.21 year (P= 0.462). HLA–DQB*03 was positive in 34% of patients. Conclusion: In this study, we do not see any significant correlation between HPV infection and HLA–DQB*03 in the studied women.