Adult Onset Still’s Disease in Oman

Objective: To 1 Highlight the demographic characteristics, clinical features, laboratory investigations and outcome ifpossible of a relatively rare disease (Adult Onset Still s Disease {AOSD}) and 2. To compare our results with those reported earlier byothers. Method: A retrospective review of the clinical, laboratory and radiological manifestations in 6 patients admitted with AOSD.Data were collected from clinical summary of each case highlighting the demographic, clinical features and relevant investigation. Thediagnosis was made on clinical base and supported by the laboratory and radiological examinations to confirm the diagnosis and/orexclude other differential diagnoses. Results: Mean age of patients (21.6), presence of fever (80.2%) and its pattern, skin rash (80.2%),arthralgia(100%), arthritis(66.65%), and the duration of morning stiffness, all these findings were compatible with earlier results. Howeveryoung adult females constitute (80.2%) of our small group, which is quite high in comparison with others. Splenomegaly (33.3%),hepatomegaly(ÆÌ6.6%), and lymphadenopathy(ÆÌ6.6%) were less than that reported by others who have more serious intra-abdominalvisceral involvement. One patient (ÆÌ6.65%) had a fatal pulmonary embolism, although usually pulmonary involvement is a mild one.None of our patients had neurological, ophthalmological or hearing involvement. The results of the investigations and radiologicalfindings are more or less similar to those in other series. Conclusion: The clinical and laboratory characteristics of our small numberof patients are more or less consistent with findings of others. It is important to keep in mind that AOSD is an uncommon syndromewith a range of signs and symptoms which are non-specific and may simulate a variety of connective tissue and general medical problems.Differences in the expression of AOSD were found between patients from different locations and the disease can be responsiblefor life-threatening complications.