Title of article :
Transient Myeloproliferative Disorder and Down Syndrome: Is there a link?
Author/Authors :
Reyes, Zenaida S. Sultan Qaboos University Hospital - Department of Child Health, Oman , Bashir, Wafa Sultan Qaboos University Hospital - Department of Haematology, Oman , Pathare, Anil Sultan Qaboos University Hospital - Department of Haematology, Oman
Abstract :
An extremely premature male neonate presented with an unusual multisystem dysfunction within the first 24 to 48 hours of life. The unfolding of clinical events and investigations revealed a transient myeloproliferative disorder (TMD). TMD was the main indication for karyotyping of this premature infant without clinical symptoms of Down syndrome. The awareness of TMD in a newborn warrants karyotype analysis to look for trisomy 21 and a close surveillance because of its potential progression to true leukaemia
Keywords :
Extreme premature , Transient myeloproliferative disorder , Down syndrome , GATA1 , Acute myelogenous leukemia (AML) , Case report , Oman
Journal title :
Sultan Qaboos University Medical Journal (SQUMJ)
Journal title :
Sultan Qaboos University Medical Journal (SQUMJ)
