Title of article :
Effect of Kebar Grass (Biophytum petersianum) Extract on the Seminiferous Tubules in Male Mice (Mus musculus) Treated With 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Author/Authors :
Ingrid Rusyawardani, Aldis Department of Veterinary Anatomy - Faculty of Veterinary Medicine - Universitas Airlangga Surabaya, Indonesia , Widjiati Department of Veterinary Anatomy - Faculty of Veterinary Medicine - Universitas Airlangga Surabaya, Indonesia , Utama, Suzanita Department of Veterinary Reproduction - Faculty of Veterinary Medicine - Universitas Airlangga Surabaya, Indonesia , Anwar, Chairul Department of Veterinary Anatomy - Faculty of Veterinary Medicine - Universitas Airlangga Surabaya, Indonesia , Maslachah, Lilik Department of Basic Veterinary Medicine - Faculty of Veterinary Medicine - Universitas Airlangga Surabaya, Indonesia , Luqman, Epy Muhammad Department of Veterinary Anatomy - Faculty of Veterinary Medicine - Universitas Airlangga Surabaya, Indonesia
Abstract :
The aim of this research was to analyze the effect of kebar grass on the seminiferous tubules diameter and
epithelium thickness of mice exposed to 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD). Twenty five BALB/C mice were
used with five treatments (4 mice each group): Negative Control (C-), Positive Control (C+) with TCDD 7µg/kgBW
IP, and treatment groups that treated with TCDD 7µg/kgBW IP and Kebar Grass orally for 53 days were presented
T1 0,045mg/gBW/day, T2 0,080mg/gBW/day, and T3 0,135mg/gBW/day. Results showed that TCDD decreased
the diameter and epithelium thickness of seminiferous tubules, while kebar grass extract was proven to maintain
diameters but could not maintain epithelium thickness of of the seminiferous tubules.
Keywords :
Kebar grass , Seminiferous tubule , Tetrachlorodibenzo-p-dioxin (TCDD) , Mice
Journal title :
Advances in Animal and Veterinary Sciences
