Author/Authors :
El-Sheikh, Sawsan M.A. Department of Pharmacology - Animal Health Research Institute, Ismailia, Egypt , Galal, Azza A.A. Department of Pharmacology - Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt , Yous, Fatma M. Department of Clinical Pathology - Animal Health Research Institute, Ismailia, Egypt , Dessouki, Amina A. Department of Pathology - Faculty of Veterinary Medicine - Suez canal university, Ismailia, Egypt , Mohamed, Haidi. I. Department of Pharmacology - Animal Health Research Institute, Ismailia, Egypt
Abstract :
In trial to investigate the effect of experimentally Pasteurella multocida , ofloxacin, Grape seed extract and
both together onhistopathological changes in rabbits, Fifty weaned rabbits were divided into five groups; control
negative (I), control positive (II), ofloxacin treated (III), GSE treated (IV) and combined treated groups (V). The result
of histopathological changes of Pasteurella infected group showed severe peribronchitis and congested blood vessels
as well as severe lymphocytic infiltrations and compensatory emphysema in lung. Liver revealed massive lymphocytic
infiltration along with fibrosis around the hepatic area. Diffuse degeneration of hepatocytes and focal necrosis were
also observed. Kidneys showed degeneration of renal tubules and focal interstitial aggregations with lymphocytes. The
animals of group III (O) and group IV (G), showed mild to moderate lesions. The group V (O+G) showed pronounced
improvement in tissues. It could be concluded that using both ofloxacin and GSE had a good effectiveness in treatment
of Pasteurellosis in rabbits.
Keywords :
asteurella multocida , Rabbit , Ofloxacin , GSE , Histopathological changes
