Author/Authors :
Krishnappa, Sarvesha Department of Pathology - Veterinary College - Hebbal - KVAFSU, Bengaluru , Satyanarayana, Mayasandra Lakshmikanth Department of Pathology - Veterinary College - Hebbal - KVAFSU, Bengaluru , Rao, Suguna Department of Pathology - Veterinary College - Hebbal - KVAFSU, Bengaluru , Yathiraj, Sreenivasa Veterinary College - Hebbal - KVAFSU, Bengaluru , Shridhar, Narayana Bhat Department of Pharmacology and Toxicology - Veterinary College - Hebbal - KVAFSU, Bengaluru , Yamanappa Mukartal, Shivalingappa Department of Veterinary Microbiology - Veterinary College - Hebbal - KVAFSU, Bengaluru , Gupta, Saurabh Division of Animal Health - Central Institute for Research on Goats (CIRG) - Makhdoom - PO-Farah - Uttar Pradesh, India , Singh, Shoorvir Division of Animal Health - Central Institute for Research on Goats (CIRG) - Makhdoom - PO-Farah - Uttar Pradesh, India , Dhama, Kuldeep Division of Pathology - Indian Veterinary Research Institute (IVRI) - Bareilly, Uttar Pradesh , Elattuvalappil, Anuradha Menon ICAR NAE Project - Veterinary College - Bengaluru, India
Abstract :
The aim of the study was to evaluate the hepatoprotective effect of AGE in AFB1 induced liver damage
in Wistar albino rats. Liver damage was induced by inoculating AFB1 (4 mg/kg BW) on day 12 of the experiment.
AGE was used (200 mg/kg BW) orally, for a period of 28 days against AFB1 induced liver injury. Histopathologically
there was periportal and centrilobular necrosis of hepatocytes and bile duct hyperplasia in AFB1 treated rats,
however, when AGE was given along with AFB1 the hepatic parenchyma was apparently normal indicating the
beneficial effect of AGE in protecting liver against AFB1 induced injury.
Keywords :
Aged garlic extract (AGE) , Aflatoxin B1 (AFB1) , Bile duct hyperplasia , Histhopathology
