Effects of colchicine on cardiac functions

We have read with great interest the article published by Hidayet et al. (1), which was regarding the effects of Behçet’s disease (BD) on cardiac repolarization. It is emphasized in the study that Tp-e interval and Tp-e/QT and Tp-e/QTc ratios were prolonged in patients with BD compared with those in healthy controls, and it was demonstrated that the Tp-e/QTc ratio was correlated with the disease duration (1). Oral aphthous ulcer and skin lesions including acneiform lesions, papulopustular lesions, and erythema nodosum are characteristic manifestations of BD. Colchicine inhibits microtubule function and decreases inflammation by impairing neutrophil chemotaxis (2). Colchicine is used in mucocutaneous manifestations of BD. It is especially effective for the treatment of oral ulcers and erythema nodosum (3). Colchicine shows some beneficial and unfavorable effects on cardiac functions. It is used in the treatment of pericarditis, and colchicine treatment is associated with significantly less recurrence following atrial fibrillation ablation (4). Frommeyer et al. (5) showed in rabbits that although colchicine had no effects on the QT interval and dispersion, effective refractory period was decreased dose dependently following colchicine infusion, indicating the significantly elevated inducibility of ventricular fibrillation (5). It is underscored in another study that colchicine treatment distinctly decreased the Tp-e and Tp-e/QT values by the end of a 1-year treatment in patients with familial Mediterranean fever (6).