Title of article
SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES
Author/Authors
Eryanti, Yum University of Riau - Organic Synthesize Laboratory, Department of Chemistry, Indonesia , Nurulita, Yuana University of Riau - Biochemistry Laboratory, Department of Chemistry, Indonesia , Hendra, Rudi University of Riau - Organic Synthesize Laboratory, Department of Chemistry, Indonesia , Yuharmen University of Riau - Organic Synthesize Laboratory, Department of Chemistry, Indonesia , Syahri, Jufrizal University of Riau - Organic Synthesize Laboratory, Department of Chemistry, Indonesia , Zamri, Adel University of Riau - Organic Synthesize Laboratory, Department of Chemistry, Indonesia
From page
117
To page
123
Abstract
Three types of cyclopentanone derivatives have been synthesized from aromatic aldehyde and ketone derivatives under a base condition through aldol condensation. These cyclopentanone products were 2,5-dibenzylidene-cyclopentanone (a), 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (b), and 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (c) which has a yield of 63-99%. The chemical structure of these compounds were determined using UV, IR and NMR spectroscopy. In order to clarify the role of hydroxyl and amine moieties, toxic, antioxidant and anti-inflammatory activities were carried out. The toxic test indicated that the compounds showed strong toxicity. In addition, the presence of hydroxyl and amine groups on both rings of curcumin increased the antioxidant and anti-inflammatory activities.
Keywords
antioxidant , anti , inflammatory , curcumin , toxicity
Journal title
Makara Journal Of Science
Journal title
Makara Journal Of Science
Record number
2594633
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