Title of article :
SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES
Author/Authors :
Eryanti, Yum University of Riau - Organic Synthesize Laboratory, Department of Chemistry, Indonesia , Nurulita, Yuana University of Riau - Biochemistry Laboratory, Department of Chemistry, Indonesia , Hendra, Rudi University of Riau - Organic Synthesize Laboratory, Department of Chemistry, Indonesia , Yuharmen University of Riau - Organic Synthesize Laboratory, Department of Chemistry, Indonesia , Syahri, Jufrizal University of Riau - Organic Synthesize Laboratory, Department of Chemistry, Indonesia , Zamri, Adel University of Riau - Organic Synthesize Laboratory, Department of Chemistry, Indonesia
Abstract :
Three types of cyclopentanone derivatives have been synthesized from aromatic aldehyde and ketone derivatives under a base condition through aldol condensation. These cyclopentanone products were 2,5-dibenzylidene-cyclopentanone (a), 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (b), and 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (c) which has a yield of 63-99%. The chemical structure of these compounds were determined using UV, IR and NMR spectroscopy. In order to clarify the role of hydroxyl and amine moieties, toxic, antioxidant and anti-inflammatory activities were carried out. The toxic test indicated that the compounds showed strong toxicity. In addition, the presence of hydroxyl and amine groups on both rings of curcumin increased the antioxidant and anti-inflammatory activities.
Keywords :
antioxidant , anti , inflammatory , curcumin , toxicity
Journal title :
Makara Journal Of Science
Journal title :
Makara Journal Of Science
