Author/Authors :
de Oliveira, Miriã R. Laboratory of Comparative Pathology - Department of General Pathology - Biological Sciences Institute, Federal University of Minas Gerais , Silveira, Tatiany L. Laboratory of Comparative Pathology - Department of General Pathology - Biological Sciences Institute, Federal University of Minas Gerais , Carneiro, Rubens A. Veterinary Hospital - Veterinary School - Federal University of Minas Gerais , Lavalle, Gleidice E. Veterinary Hospital - Veterinary School - Federal University of Minas Gerais , Rodrigues, Michele A. Laboratory of Comparative Pathology - Department of General Pathology - Biological Sciences Institute, Federal University of Minas Gerais , Cassali, Geovanni D. Laboratory of Comparative Pathology - Department of General Pathology - Biological Sciences Institute, Federal University of Minas Gerais
Abstract :
We report four cases of disseminated tumor cells (DTCs) present in the bone marrow (BM) of canines with
inflammatory mammary carcinoma (IMC). The diagnosis was made by cytological and histopathological analysis of
BM biopsy and was confirmed by immunohistochemistry and immunofluorescence methods using an anti-cytokeratin
AE1/AE3 antibody. The cytologic evaluation followed by BM immunocytochemistry is a widely used method for the
investigation of DTCs in women with breast neoplasms. Few studies have reported the presence of these cells in dogs,
including IMC. The presence of these cells in the BM of women with breast tumors is related to tumor recurrence.
This study demonstrates the presence of DTCs in the BM of dogs with IMC. Furthermore, the observation of the
presence of micrometastasis at the time of diagnosis combined with cytokeratin immunocytochemical analysis could
be a valuable prognostic tool in veterinary patients.
Keywords :
Bone marrow , Disseminated tumor cells , Metastasis , Inflammatory carcinoma , Dog
