Title of article :
Flavonoid Compounds from the Bark of Aglaia eximia (Meliaceae)
Author/Authors :
Sianturi, Julinton Universitas Padjadjaran - Faculty of Mathematics and Natural Sciences - Department of Chemistry, Indonesia , Purnamasari, Mayshah Universitas Padjadjaran - Faculty of Mathematics and Natural Sciences - Department of Chemistry, Indonesia , Mayanti, Tri Universitas Padjadjaran - Faculty of Mathematics and Natural Sciences - Department of Chemistry, Indonesia , Harneti, Desi Universitas Padjadjaran - Faculty of Mathematics and Natural Sciences - Department of Chemistry, Indonesia , Supratman, Unang Universitas Padjadjaran - Faculty of Mathematics and Natural Sciences - Department of Chemistry, Indonesia , Awang, Khalijah university of malaya - Faculty of Science - Department of Chemistry, Malaysia , Hayashi, Hideo Osaka Prefecture University - Graduate School of Life and Environmental Sciences - Division of Applied Life Sciences, Japan
Abstract :
Three flavonoid compounds, kaempferol (1), kaempferol-3-O-α-L-rhamnoside (2), and kaempferol-3 -O-β-D-glucosyl- α-L-rhamnoside (3), were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of compounds 1–3 were identified with spectroscopic data, including UV, IR, NMR (1^H, 13^C, DEPT 135°, HMQC, HMBC, 1^H-1^HCOSY NMR), and MS, as well as a compared with previously reported spectra data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1–3 showed cytotoxicity against P-388 murine leukemia cells with IC_50 values of 1.22, 42.92, and 100 mg/mL, respectively.
Keywords :
Aglaia eximia , cytotoxic activity , flavonoid compound , Meliaceae
Journal title :
Makara Journal Of Science
Journal title :
Makara Journal Of Science
