Author/Authors :
Shirani, Ihsanullah The State Key Laboratory of Agricultural Microbiology - Huazhong Agricultural University, Wuhan, China , Marawa, Marawan A. The State Key Laboratory of Agricultural Microbiology - Huazhong Agricultural University, Wuhan, China , Rahi, Najibullah Para clinic Department - Faculty of Veterinary Medicine, Nangarhar University, Nangarhar, Afghanistan , Dawood, Ali The State Key Laboratory of Agricultural Microbiology - Huazhong Agricultural University, Wuhan, China
Abstract :
Clostridium difficile is an important emerging infectious agent and might colonize in digestive tract of
humans. C. difficile exhibits a low level of gene conservation. Consequently, antibiotic therapy result has demonstrated
in 15-30% cases. In the current review we summarized up to date information about the drug resistance genotypes
of C. difficile for the first time. Our study revealed that there was a steady difference among various genotype. Which
demonstrated that mutations in the DNA genes was very common in the antibiotic resistance phenotypes. Together
our data revealed that antibiotic resistivity poses selective pressure on the genome of C. difficile that could lead to more
adoptable drug resistance strains. This study may open a new avenue for the research in understanding the mechanism
of C. difficile adaptation to antibiotics and the development of new antibacterial. However, their further research is
needed to exploring C. difficile genomic diversity changed from molecular typing assays to total-genome sequence
comparisons and comparative genome microarrays.
Keywords :
Clostridium difficile , Ribotypes , Whole genomic analysis , BLAST , Genome
