Author/Authors :
Sunil Kumar, Mavidi Department of Internal Medicine - All India Institute of Medical Sciences - New Delhi 110029, India , Singh, Akanksha Department of Physiology - All India Institute of Medical Sciences - New Delhi 110029, India , Kumar Jaryal, Ashok Department of Physiology - All India Institute of Medical Sciences - New Delhi 110029, India , Ranjan, Piyush Department of Internal Medicine - All India Institute of Medical Sciences - New Delhi 110029, India , Deepak, K. K. Department of Physiology - All India Institute of Medical Sciences - New Delhi 110029, India , Sharma, Sanjay Department of Radiodiagnosis - All India Institute of Medical Sciences - New Delhi 110029, India , Lakshmy, R. Department of Cardiac Biochemistry - All India Institute of Medical Sciences - New Delhi 110029, India , Pandey, R. M. Department of Biostatistics - All India Institute of Medical Sciences - New Delhi 110029, India , Vikram, Naval K. Department of Internal Medicine - All India Institute of Medical Sciences - New Delhi 110029, India
Abstract :
Aim. The present study was designed to evaluate the heart rate variability (HRV) in nonalcoholic fatty liver disease (NAFLD) and
to assess the effect of grade of NAFLD and diabetic status on HRV. Methods. This cross-sectional study included 75 subjects (25
NAFLD without diabetes, 25 NAFLD with diabetes, and 25 controls). Measurements included anthropometry, body composition
analysis, estimation of plasma glucose, serum lipids, hsCRP, and serum insulin. HRV analysis was performed in both time and
frequency domains. Results. The time and frequency domain indices of overall variability (SDNN, total power) were significantly
lower in NAFLD with diabetes as compared to the controls. However, the LF : HF ratio did not differ among the three groups. The
variables related to obesity, lipid profile, and glucose metabolism were also higher in NAFLD with diabetes and those with Grade II
NAFLD without diabetes, as compared to controls. Multivariate stepwise regression analysis showed a negative correlation between
HRV and total cholesterol and fat percentage. Conclusion. The grade of NAFLD as well as diabetic status contributes to the decrease
in the cardiovascular autonomic function, with diabetic status rather than grade of NAFLD playing a critical role. Serum lipids and adiposity may also contribute to cardiac autonomic dysfunction.
