TheImpact of Hyperthyroidism on Selected Serum Proteinsand Metal Ions in the Population of Lahore and itsSurrounding Areas

Inorganic metal ions and the proteins play an essential role in living systems. Different hormonesand cellular messengers regulate the hemostasis of organisms. Calcium, magnesium, iron and zincare abundantly distributed in human bodies and play vital role in many biochemical processes.Albumin and ferritin are also the most abundant proteins present in our bodies and carrying outimportant physiological processes. A disease state or a medical condition can perturb the normallevels of metal ions and proteins in living systems. In the present study, we have analyzed theserum concentration of Ca, Mg, Fe, Zn, albumin and ferritin of hyperthyroid patients.This studyincludes 184 collected samples (52 normal subjects and 132 hyperthyroid patients), with agegroup ranging between 11 to 75 years. During sample collection, only those patients wereincluded for whom hyperthyroidism was initially diagnosed but not taking any medicines yet. Thehyperthyroid state was determined by the correlation of FT3, FT4and TSH. SerumFe,Caandalbumin levels were determined by spectrophotometric method, whileZuandMgby atomicabsorption spectroscopy (AAS) and ferritin by radioimmunology assay (RIA). Obtained resultsdemonstrated the significant differences in the studied parameters as compared to the normalsubjects.