Glutathione S-Transferase Z1 Gene Polymorphism in Turkish Population

Objective: Glutathione S-Transferase zeta (GSTZ1) is a new member of glutathione S-transferase isoenzymes. There are several polymorphic regions in the GSTZ1 gene. The result of two base changes at nucleotide positions 94 and 124, GSTZ1 gene has four alleles, GSTZ1*A (A94A124), GSTZ1*B (A94G124), GSTZ1*C (G94G124) and GSTZ1*D (G94A124). The aim of the present study was to investigate the distribution of GSTZ1 gene polymorphism in the Turkish population. Material and Methods: Eighty unrelated healthy subjects who were admitted to the hospital from the Mersin region were included in the study and DNA samples were extracted from the lymphocytes by using High Pure Template Preparation Kit. The polymorphism of GSTZ1 was performed by PCR-RFLP in Turkish population. Results: The distributions of GSTZ1*A, GSTZ1*B, GSTZ1*C and GSTZ1*D allele frequencies are 1.2%, 20%, 76.9% and 1.9%, respectively. Conclusion: This study presents the first results of GSTZ1 allele distributions in the Turkish population. In the present study the frequency of GSTZ1*A allele was lower than in the other populations.