Author/Authors :
Keklik, Muzaffer Kayseri Training and Research Hospital - Clinic of Hematology, Turkey , Büyükoğlan, Rüksan Erciyes University - School of Medicine - Department of Genetics, Turkey , Şıvgın, Serdar Erciyes University - School of Medicine - Department of Hematology, Turkey , Eser, Bülent Erciyes University - School of Medicine - Department of Hematology, Turkey , Kaynar, Leylagül Erciyes University - School of Medicine - Department of Hematology, TURKEY , Çetin, Mustafa Erciyes University - School of Medicine - Department of Hematology, Turkey , Ünal, Ali Erciyes University - School of Medicine - Department of Hematology, Turkey , Keklik, Ertuğrul Erciyes University - School of Medicine - Department of Physiology, Turkey , Özkul, Yusuf Erciyes University - School of Medicine - Department of Genetics, Turkey
Abstract :
Objective: Myelodysplastic syndrome (MDS) represents one of the most frequent and serious hematologic diseases among the elderly. Chromosomal abnormalities have been detected in 23%–78% patients with MDS. We analyzed the cytogenetics of elderly MDS patients in Turkey. Materials and Methods: Data on patients ( 65 years old) diagnosed with primary MDS from 2011 to 2013 were retrospectively collected from Erciyes University. Chromosome analysis was performed in 54 patients using conventional karyotyping and fluorescence in situ hybridization (FISH). Results: Of the 54 patients recruited, karyotype abnormalities were found in 8 (15%) of 54 cases, among which, 5 (9%) were Trisomy 8 and 3 (6%) were del 5q. Conclusion: The incidence of chromosomal abnormalities in elderly Turkish MDS patients was lower than that reported in the literature. Although the pathogenesis of MDS is still poorly understood, environmental and biological factors could induce mechanisms that are associated with diverse karyotypes and variable frequencies of chromosomal abnormalities.
