Author/Authors :
Doan, Ky Thai Department of Gastroenterology and Hepatology - 108 Military Central Hospital - Hanoi, Vietnam , Nguyễn Việt, Long Department of Medical Oncology - 108 Military Central Hospital - Hanoi, Vietnam , Nguyen Tien, Thinh Department of Gastroenterology and Hepatology - 108 Military Central Hospital - Hanoi, Vietnam , Nguyen Canh, Binh Department of Gastroenterology and Hepatology - 108 Military Central Hospital - Hanoi, Vietnam , Ngo Thi, Hoai Department of Gastroenterology and Hepatology - 108 Military Central Hospital - Hanoi, Vietnam , Nguyen Thanh, Ngoc Department of Medical Oncology - 108 Military Central Hospital - Hanoi, Vietnam , Bui Quang, Bieu Department of Radiation Oncology and Radiosurgery - 108 Military Central Hospital, Vietnam , Van, Quang Le Department of Oncology - Hanoi Medical University Hospital, Vietnam , Woong Lee, Hyun Department of Internal Medicine - Yonsei University College of Medicine - Gangnam Severance Hospital - Seoul - Republic of Korea , Mai Hong, Bang Department of Gastroenterology and Hepatology - 108 Military Central Hospital - Hanoi, Vietnam
Abstract :
Introduction. Survival outcomes in patients with unresectable colorectal cancer (CRC) liver metastasis treated by radiofrequency
ablation (RFA) combined with systemic chemotherapy and correlation with potential prognostic factors were investigated.
Material and Methods. A retrospective cohort study was conducted on 61 CRC patients with unresectable liver metastasis who
underwent liver tumor-directed percutaneous RFA combined with conventional systemic chemotherapy between October 2013
and September 2018. Survival analyses were conducted using the Kaplan-Meier method, and the log-rank test was used to
characterize differences in the median survival time and the 1-year, 3-year, and 5-year overall survival rates of subgroups to
identify prognostic factors. Results. Median overall survival and progression-free survival of all patients were 32 and 14 months,
respectively. The cumulative survival rates at 1-, 3-, and 5-years were 93.2%; 44.5%, and 38.2%, respectively. Univariate analysis
revealed that pre-RFA serum CEA levels, Eastern Cooperative Oncology Group (ECOG) status, number of liver lesions, the size
of the largest lesion, and the total lesion size were prognostic factors. However, multivariate analysis demonstrated that only the
number of liver lesions and the size of the largest lesion were independent prognostic factors for survival. Conclusion. RFA plus
systemic chemotherapy provides an encouraging survival outcome for patients with unresectable CRC liver metastasis. Multivariate analysis demonstrated that the number and size of livermetastatic lesions are independent prognosticfactorsfor survival.
Keywords :
Prognostic Factors , Radiofrequency Ablation plus Systemic , Chemotherapy , Unresectable Colorectal Cancer , Liver Metastasis
