Author/Authors :
Wan Ismail, Wan Iryani Universiti Teknologi MARA - Faculty of Pharmacy - Department of Pharmaceutical Life Science, Malaysia , Abu, Mohd Nazri Universiti Teknologi MARA - Faculty of Health Sciences - Department of Medical Laboratory Technology, Malaysia , Salleh, Muhammad Ashraf Mohd Universiti Teknologi MARA - Faculty of Pharmacy - Department of Pharmaceutical Life Science, Malaysia , Zainol, Izmil Haikal Universiti Teknologi MARA - Faculty of Pharmacy - Department of Pharmaceutical Life Science, Malaysia , Yusoff, Rosmadi Mohd Universiti Teknologi MARA - Faculty of Pharmacy - Department of Pharmaceutical Life Science, Malaysia
Abstract :
Cell signalling is part of a strategy in drug discovery. Among the focus is by studying the insulin and insulin-like growth factor (IGF1R) signalling pathways. The molecular mechanism of insulin and IGF1R signalling pathways have been studied extensively. Both pathways are vital in many of the mechanisms in human body particularly in regulating the metabolism and cell growth. Besides, both pathways have been found to be involved in numerous diseases such as in various types of cancer. This review briefly revealed the information on the pathways, their correlations and current findings in cancer study.
Keywords :
cancers , cell signalling , insulin , insulin , like growth factor signalling pathways
