CLINICAL AND BIOCHEMICAL EVALUATION OF PERIOFILM® AS AN ADJUNCT TO NON-SURGICAL PERIODONTAL THERAPY

The objective of this study was to evaluate the clinical and biochemical effects of local sodium piperacillin (Periofihn®) therapy used as an adjunct to scaling and root planning (SRP) in chronic periodontitis patients. A total of 20 patients with probing depth (PD) ≥ 5mm and gingival index (GI)≥ 2 in at least 2 single-rooted teeth were included. Group 1 received SRP, whereas group 2 received SRP + Periofilm® application. The clinical and biochemical parameters were monitored over a period of 90 days. At 0. and 90. days, plaque index, GI, PD, relative attachment level and gingival recession were measured. At the same days, gingival crevicular fluid (GCF) samples were also collected. After determination of GCF volume, matrix metalloproteinase-8 (MMP-8) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) levels were measured by ELISA. At 90 days in SRP and SRP+Periofilm® groups, mean PD reduction of 2.2±0.8 mm and 2.28±0.68 mm, attachment gain of 1.49±0.84 mm and 1.71±1.00 mm, recession of 0.71±0.58 mm and 0.56±0.92 mm were found respectively (p 0.05). All periodontal sites treated with either SRP or SRP+Periofilm® revealed a decrease in MMP-8 concentration and an increase in TIMP-1 concentration which was parallel to the clinical parameters (p 0.001). Considering all parameters, no significant intergroup changes were found between the groups (p 0.05). Under the light of our findings, it can be concluded that initial periodontal therapy is essential in consolidating clinical and biochemical improvements. Both treatment groups responded to therapy with similar resolution of infection reflected to clinical and biochemical parameters.