Title of article :
A Fourier Transform Infrared Spectrophotometry Method Used For Oseltamivir Determination in Pharmaceutical Formulations
Author/Authors :
BUNACIU, Andrei A. S.C. CROMATEC_PLUS S.R.L. - SCIENT - Research Center for Instrumental Analysis, ROMANIA , NITA, Sultana National Institute for Chemical Pharmaceutical Research and Development, ROMANIA , FLESCHIN, Şerban University of Bucharest - Faculty of Chemistry - Department of Organic Chemistry, Biochemistry and Catalysis, ROMANIA , AYDOĞMUŞ, Zeynep Istanbul University - Faculty of Pharmacy - Department of Analytical Chemistry, TURKEY , ABOUL-ENEIN, Hassan Y. Pharmaceutical and Medicinal Chemistry Department - Pharmaceutical and Drug Industries Research Division, EGYPT
Abstract :
A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of oseltamivir phosphate (OP) in pharmaceutical formulations. Conventional KBr-spectra were compared for best determination of the active substance in pharmaceutical preparations. The Beer-Lambert law and two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods, were used in data processing.
Keywords :
FT , IR analysis , oseltamivir , chemometric methods , pharmaceutical analysis.
Journal title :
Gazi University Journal Of Science
Journal title :
Gazi University Journal Of Science
