Synthesis, Characterization and the Photodynamic Activity against Some Gram Negative and Positive Bacteria of Novel Subphthalocyanine Derivative

A specific tris(3,5-di-tert-butyl-4-hydroxyphenyl)Subphthalocyaninehydroxyde (SubPc-1) derivative was synthesized and the structure of SubPc-1 was confirmed by UV-Vis, Fluorescence, FTIR, ^1 H NMR, ^13 C NMR and MALDI-TOF-MS spectroscopy. Its thermal stability and photostability tests were checked by using TGA and solar simulator, respectively. In addition, the singlet oxygen produced capacity of amphiphilic SubPc-1 was determined for PDT studies. Besides, the photodynamic activity of this novel product against some of gramnegative bacteria (Escherichia coli, Pseudomonas aeruginosa) and gram positive bacteria (Staphylococus aureus, Enterococcus faecalis) has been investigated by using a xenon lamp which emits light in the ultravioletvisibleregion and is simulated for solar light as the illumination source. It was determined that the peripheralhydrophilic groups provided great opportunities in inactivation and solubility studies. This new amphiphilicmacromolecule was especially found as an effective photosensitizer against gram positive bacteria in PDT, inparticular.