Title of article :
Lead nitrate induced oxidative stress in brain tissues of rats: Protective effect of sodium selenite
Author/Authors :
Kalender, Suna Gazi Üniversitesi - Gazi Education Faculty - Department of Science Education, Turkey , Apaydin, Fatma Gokce Gazi Üniversitesi - Faculty of Science - Department of biology, Turkey , Demir, Filiz Gaziosmanpasa University - Graduate School of Natural and Applied Sciences, Turkey , Bas, Hatice Bozok University - Faculty of Arts and Science - Department of Biology, Turkey
Abstract :
Lead used in many industrial applications and it has been recognized as a toxic metal. The aim of this study is to investigate the effects of lead nitrate on brain tissues of diabetic and non-diabetic rats and the protective role of sodium selenite. Four weeks later,changes in antioxidant enzyme activities and MDA levels determined in the brain tissues. At the end of the study,we showed that lead nitrate causes oxidative stress in diabetic and non-diabetic rat brain and the sodium selenite can ameliorate this toxicity,but not protect completely.
Keywords :
Antioxidant enzymes , Brain , Lead nitrate , Oxidative stress , Sodium selenite
Journal title :
Gazi University Journal Of Science
Journal title :
Gazi University Journal Of Science
