Author/Authors :
Mohammadi-Nasab, Mohammadreza Physiology-Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences - Rafsanjan, Iran - Department of Physiology and Pharmacology - School of Medicine - Rafsanjan University of Medical Sciences - Rafsanjan, Iran - Student Research Committee - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Fatemi, Iman Research Center for Tropical and Infectious Diseases - Kerman University of Medical Sciences - Kerman, Iran , Pak-Hashemi, Mohammad Physiology-Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences - Rafsanjan, Iran - Department of Physiology and Pharmacology - School of Medicine - Rafsanjan University of Medical Sciences - Rafsanjan, Iran - Student Research Committee - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Abbasi-Fard, Mitra Molecular Medicine Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences - Rafsanjan, Iran - Department of Internal Medicine - Ali-Ebn Abitaleb Hospital - Rafsanjan University of Medical Sciences - Rafsanjan, Iran , Hassanipour, Mahsa Physiology-Pharmacology Research Center - Research Institute of Basic Medical Sciences - Rafsanjan University of Medical Sciences - Rafsanjan, Iran - Department of Physiology and Pharmacology - School of Medicine - Rafsanjan University of Medical Sciences - Rafsanjan, Iran
Abstract :
Introduction: Polycystic ovary syndrome (PCOS) is associated with many complications. Neurobehavioral deficits are reported in women with PCOS. Patients with PCOS show a high risk for affective disorders, which impair the quality of life. Finding a safe herbal medicine for these complications is valuable. Pistacia vera plays a beneficial role in central nervous disorders. The current study is designed to evaluate the effects of Pistacia vera oil on depression and anxiety-like behaviors in female rats with letrozole-induced PCOS. Methods: Letrozole (1 mg/kg) was used orally in order to induce PCOS. Pistachio oil (1 and 4 ml/kg) was administered with letrozole. After 21 days, elevated plus-maze test, forced swimming test (FST), and open field tests were performed. Results: The data showed that the PCOS condition led to immobility time enhancement in the FST (P<0.001). PCOS animals significantly exhibited anxiety-like behaviors (P<0.05). Treatment with pistachio oil with doses of 1 and 4 ml/kg completely blocked the deleterious effects of PCOS on behavioral parameters. Conclusion: Pistacia vera oil could alleviate depression and anxiety in rats with PCOS.
Keywords :
Pistacia vera , Polycystic Ovary Syndrome , Anxiety , Depression , Rat
