A Meta-Analysis of the Effect of Antimicrobial Peptide Purity on the Growth Performance, Dry Matter Digestibility, and Intestinal Morphology of Broiler

This meta-analysis aimed to systematically evaluate the effect of the administration of antimicrobial (AMP) both in form of single AMP (SAP) and composite AMP (CAP) on the growth performance, dry matter digestibility, and intestinal morphology of broiler. Data tabulation only involved credible international journals as indicated by Scopus indexed, equipped with doi number, and ranked in the scientific journal rankings cluster. There were 68 experiments with 210 datum collected from 33 literatures. The data were analyzed using a linear mixed model. The differences between the experiments were noted as random effects, while the purity of AMP was determined as fixed effects. The AMP purity significantly (P <0.05) improved the several observed variables, such as body weight, average daily gain, feed conversion ratio, and dry matter digestibility both in the starter period, finisher period, and total period of broiler. It also significantly improved intestinal morphology in the duodenum (alike villus height), jejunum (alike crypt depth), and ileum (like villus height and crypt depth). Compared to CAP, SAP supported better performance on most of observed variables. In short, the AMP could bring positive effect on the growth performance, dry matter digestibility, and intestinal morphology of broiler not only in starter, finisher but also in total of period of broiler. Compared to CAP, the administration of SAP showed a greater performance on broiler.