Survey on Effects of Pistacia Atlantica Gum Extract on Some Enzymes and Biochemical Factors Arising from ''Cisplatin'' in the Serum of Male Wistar Rats

Introduction: Cisplatin is an anticancer drug used for tumor treatment, causing free radicals and damaging the DNA. The higher doses of cisplatin induce toxicity in organs, such as the kidney and liver. Regarding antioxidant properties of Pistacia Atlantica gum containing flavonoid compounds, this study aims to investigate the protective effects of the gum on Wistar rat's liver and kidney cells against cisplatin toxicity. Materials and Methods: Emulsion was made from Pistacia Atlantica gum using the self-emulsification method to facilitate rats' gavage. Then, 24 male Wistar rats were randomly divided into 4 groups, including the control group (CG), extract group (EG), gum & cisplatin group (GCG), and cisplatin group (CiG). Subsequently, the concentration of malondialdehyde (MDA), total protein (TP), total antioxidant capacity (TAC), the activity of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX) were measured in rat's blood samples for 15 days. One-way ANOVA was used to demonstrate differences between groups by SPSS Ver.2018 software. Results: Pistachio Atlantica gum significantly halted the reduction effects of cisplatin on GPX, CAT, and SOD in group 3. It displayed a significant increase in TAC and a remarkable reduction in MDA. Conclusion: Pistachio Atlantica gum appeared to have protective and moderate effects against cisplatin-induced toxicity on the liver and kidney. Moreover, its antioxidant attributes caused a reduction in free radicals.