Estimation of Ceruloplasmin activity, and copper, iron levels in sera of nor1nal pregnants

This study was undertaken to shed light on the changes of levels of CP acti vity, Cu and Fe in sera of (53) normal non-smoker pregnants without complication. dur ing three trimesters of pregnancy. Gl in cl_ude ( 18) ;re_gnants in the 1st trimester, G2 (19) pregnan_ts wear taken m the 2 tnmester and 03 ( 16) pregnants m the 3 rd tnmester. Another ( 18) serum sanTples were taken from healthy non-pregnant women age matched as control group G4. Results showed a significant steady elevation in CP actjvity and sennJl Cu with advanced trimester of pregnancy compared to control. The iron concentrations in the sera of pregnant women showed a s-ignilicc,tnt reduction compared to control group ·also a steady decrease in Fe levels with advanced trimoster was found. TheThe merased activities in CP as ·endogenous antioxidant durin g advanced pregnancy could be . acounter balance to the free radical generation due to the in.creaSe in Cu concentration With advance gestation.