Title of article :
Univariate and Simplex Optimization for The Analysis of Diphenhydramine-HCl Through Ion-pair Formation
Author/Authors :
Mohammed, A. K. University of Baghdad - College of Education Ibn Al Haitham - Department of Chemistry, Iraq , Dikran, S. B. University of Baghdad - College of Education Ibn Al Haitham - Department of Chemistry, Iraq , Alubydi, M. Abdul Sattar University of Baghdad - College of Education Ibn Al-Haitham - Department of Chemistry, Iraq
Abstract :
A Simple, rapid and sensitive extractive and sp ectrophotometric method has been described for the analysis of diphenhyldramine –HCl (DPH) in pure form and in pharmaceutical formulations. The method is based on the formation of chloroform soluble ion-pair complex with Bromophenol blue(BPB) in a phthalate buffer at p H 3.0.The extracted complex shows maximum absorbance at 410 nm. Beer s law is obeyed in the concentration range 0.2-25.0 μg.ml-1. The molar absorptivity and Sandell s sensitivity for the system being2.416x104 L.mol-1.cm-1 and 0.012μg.cm-2, respectively. The limit of detection was found to be0.155 μg.ml-1. The proposed method was successfully applied to the determination of the drug in pharmaceutical formulation and satisfactory results were obtained
Keywords :
The Analysis of Diphenhydramine , HCl Through Ion , pair Formation , Univariate and Simplex Op timization
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
