Title of article :
Synthesis, Spectroscopic and Biological Studies of Some Metal Complexes with 2,3,5,6- O,O,O,O-tetraacetic acid Lascorbic acid
Author/Authors :
Sultan, J. S. University of Baghdad - College of Education, Ibn Al- Haitham - Department of Chemistry, Iraq , Mukhlus, A. A. University of Baghdad - College of Education Ibn Al- Haitham - Department of Chemistry, Iraq , Musa, F. H. University of Baghdad - College of Education, Ibn Al- Haitham - Department of Chemistry, Iraq
Abstract :
The reaction of L-ascorbic acid with the chloroacetic acid in presence of potassium hydroxide has been investigated. The new product L (2,3,5,6-O,O,O,O-tetraacetic acid L-ascorbic acid) was isolated and characterized by elemental analysis(C.H), 1H, 13C-NM R. Mass sp ectrum and Fourier transform infrared (FT-IR). The reaction of the ligand (L) (where L = H4L), M+2 = (Co, Ni, Cu, Cd, Pb, Hg, Ca, Mg) has been investigated and was isolated and characterized by FT-IR, UV- visible, conductivity, Atomic absorption and molar ratio (Cd, Co) complexes. Spectroscopic evidence showed that the binding of the M(II) ions are throughy the O-1 Lacton, O-2-OCH2COOH and O-6-OCH2COOH resulting in a six- coordinated metal ion, , Kf, max, for Co, Cd complexes, were estimated, for Co, Ni, complexes were calculated too. The study of biological activity of the ligand (L) and its complexes (Cu+2, Cd+2, Ca+2) showed various activity toward staphylococcus aureu and Escherichia coli, except Cacomplex didn t show any effect
