Title of article :
Synthesis of Some New Metal Complexes of 5,6-OIsopropylidene- 2,3,-O,O Acetic Acid-L-Ascorbic Acid and Evaluation their Biological Activity
Author/Authors :
Sultan, J. S. University of Baghdad - College of Education, Ibn Al- Haitham - Department of Chemistry, Iraq , Mukhlus, A. A. University of Baghdad - College of Education Ibn Al- Haitham - Department of Chemistry, Iraq , Musa, F. H. University of Baghdad - College of Education, Ibn Al- Haitham - Department of Chemistry, Iraq
Abstract :
Stable new derivative of L-ascorbic acid, 5,6-O-iso propylidene 2,3-O,O acetic acid-Lascorbic acid (L) was sy nthesized in good yield by the reaction of 5,6-O-isopropylidene-Lascorbic acid with chloroacetic acid in presence of potassium hydroxide. The new product (L) was characterized by 1H, 13C–NM R, mass sp ectrum and fourier transform infrared (FTIR). The reaction of the ligand (L) with metal bivalent ion., M^+2 = (Co, Ni, Cu, Cd, Hg, Mg, Ca, Pb) sy nthesized and characterized by FTIR, UV-Visible, Molar conductance, Atomic absorp tion and the molar ratio (Ni^+2, Cd^+2) complexes. Spectroscopic evidence showed that the binding of the M(II) ions with (L) are through the (C–I=O) Lacton and O-2-CH2COO– as a bidentate manar resulting in a six– coordinated metal ion; the values of α , KF, ΔG were estimated for Cd^+2, Ni^+2 complexes and , B value, for Co^+2, Ni^+2 complexes were calculated too. The study of biological activity of the ligand (L) and (Cd^+2, Cu^+2, Ca^+2) complexes showed various activities toward staphylococcus aureu and Escherichia coli, except Cacomplex didn t show any effect.
