Title of article :
Synthesis and Antibactrial Study of New 2-Amino-5-Aryl- 1,3-Thiazole-4-Carboxylic Acid Derivatives
Author/Authors :
Al- Dulaimy, Zina K. University of Wassit - College of Medicine - Dept of Medical Chemistry, Iraq , Kadhim, Aoras A. University of Wassit - College of Medicine - Dept of Medical Chemistry, Iraq , Attia, Abduljabbar Kh. Al-Mustansiriya University - College of Science - Dept of Chemistry, Iraq , Thani, Mohammed Z. Al-Mustansiriya University - College of Science - Dept of Chemistry, Iraq
Abstract :
2-Amino-5-aryl- 1,3-thiazole-4-carboxylic acid (A1-A3) were synthesized from the reaction of various aromatic aldehyde with dichloro acetic acid and thiourea. The synthesis of 2-[[(S-aminosulfinim- idoyl)(aryl)methyl](benzoyl)amino]-5-aryl-1,3-thiazole-4-carboxylic acid (A22-A30) was perfomed starting from (A1-A3) by two steps using Schiff s base (A4-A12) prepared from the reactant compounds (A1-A3) with different aromatic aldehyde. Finally two types of imide derivatives were obtained from reactant compounds (A1-A3) with malic anhydride (A31-A33) and phthalic anhydride (A34-A36) in the presence of glacial acetic acid. All proposed structures were supported by FT-IR and UV-Visible spectroscopic data.
Keywords :
1 , 3 , thiazole , 4 , carboxylic acid , imide derivatives , Schiff s base.
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
