Title of article :
Synthesis and antimicrobial evaluation of new 1,3,4 – Thiadiazole Derivatives
Author/Authors :
mustafa, iman f. university of baghdad - college of education for pure science (ibn al-haitham) - department of chemistry, Iraq , hussain, eman m. university of baghdad - college of education for pure science (ibn al-haitham) - department of chemistry, Iraq
Abstract :
The amino thiadiazole [I] on treatment with aromatic aldehydes yielded Schiff bases
[IIa-c] , which cyclized to thiazolidinone [IIIa-c] derivatives by reaction with thioglycolic acid
.Reaction of carbon disulfide and methyl iodide with [I] gavedithiomethyl[IV] which on
treatment with o-phenylenediamine gave the condensed N-Imidazolythiadiazolylamine [V] ,
However , reaction of [I] with phenylisocyanate and phenylisothiocyanate afforded the
carbamideand carbothiamide derivatives[VI.VII]a-c.
The structure of these compounds was characterized from their melting point , FTIR
spectroscopy and elementalanalysis .
Keywords :
thiadiazolylamine , imidazoly , thiazolidinone , antimicrobial 1,3,4–Thiadiazole
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
