Synthesis and Characterization of Some O-[2-{ 2-Substituted Aryl ( 1, 3, 4 thia diazolyl) [ 3, 4- b]- 1, 2, 4- Triazolyl]-Ethyl]-p- chlorobenzald oxime Derivatives.

stract In this study new derivatives of O-[2-{''2-Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4- b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime (6-11) have been synthesized from the starting material p-chloro – E- benzaldoxime 1. Compound 2 was synthesized by the reaction of p-chloro – E- benzaldoxime with ethyl acrylate in basic medium. Refluxing compound 2 with hydrazine hydrate in ethanol absolute afforded 3. Derivative 4 was prepared by the reaction of 3 with carbon disulphide, treated of compound 4 with hydrazine hydrate gave 5. The derivatives (6-11) were prepared by the reaction of 5 with different substitutes of aromatic acids. The structures of these compounds were characterized from their melting points, infrared spectroscopy, elemental analysis and 1 HNMR (some of them). Compounds (6-11) were exhibited biological activity against E- coli bacteria. Compound 9 exhibited higher degree of activity than the other.