Title of article :
Spectrophotometric Determination of Sulfamethoxazole with P-N,N-dimethyl amino benzaldehyde as Condensation Reaction
Author/Authors :
darweesh, samar a. university of baghdad - college of education for pure science(ibn al-haitham) - dept of chemistry, Iraq , al-haidari, ibdul mohsin a. university of baghdad - college of education for pure science(ibn al-haitham) - dept of chemistry, Iraq , mohammed, alaa k. university of baghdad - college of education for pure science (ibn al- haitham) - department of chemistry, Iraq , dikran, sarmad b. university of baghdad - college of education for pure science(ibn al-haitham) - dept of chemistry, Iraq
Abstract :
Sulfamethoxazole (SMX) was added to P-N,N-dimethyl amino benzaldehyde (PDAB) by condensation reaction in acidic medium to form, a yellow colored dye compound which exhibits maximum absorption (λmax) at 450.5 nm. The concentration of (SMX) was determined spectrophotometrically. The optimum reaction conditions and other analytical parameters were evaluated. In addition to classical univariate optimization, design of experiment method has been applied in optimization of the variables affecting the color producing reaction. Beer’s law obeyed in the concentration range of 0.1-10 μg.mL-1 with molar absorptivity of 5.7950×104 L.mol-1.cm-1. The limit of detection and Sandell s sensitivity value were 0.078 μg.mL-1 was 4.3706 μg.cm-2 respectivily. The proposed method could be successfully applied to the determination of (SMX) in synthetic sample and urine
Keywords :
Spectrophotometric determination , Sulfamethoxazole , Condensation reaction , P , N , Ndimethyl amino benzaldehyde
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
Journal title :
Ibn Alhaitham Journal For Pure and Applied Science
