Author/Authors :
Zhang, Li-qian Gynecology Department - Taizhou Central Hospital, Zhejiang, China , Lv, Rong-wei Gynecology Department - Taizhou Central Hospital, Zhejiang, China , Qu, Xiang-dong Gynecology Department - Taizhou Central Hospital, Zhejiang, China , Chen, Xian-jun Clinical Laboratory - Taizhou Central Hospital, Zhejiang, China , Lu, Hong-sheng Pathology Department - Taizhou Central Hospital, Zhejiang, China , Wang, Ying Gynecology Department - Taizhou Central Hospital, Zhejiang, China
Abstract :
Aloesin is an active constituent of the herb aloe vera and plays a crucial role in anti-inflammatory activity, ultraviolet protection, and antibacterium. We investigated the role and possible mechanisms of aloesin in the cell growth and metastasis of ovarian cancer. It was found that aloesin inhibited cell viability and cell clonality in a dose-dependent manner. It arrests the cell cycle at the S-phase and induced apoptosis in SKOV3 cells. In an in vivo experiment, it was observed that aloesin inhibited tumor growth. Moreover, it inhibited migration and invasion of cancer in SKOV3 cells. Interestingly, members from the mitogen-activated protein kinase (MAPK) signaling family became less phosphorylated as the aloesin dose increased. This suggests that aloesin exerts its anticancer effect through the MAPK signaling pathway. Our data also highlights the possibility of using aloesin as a novel therapeutic drug for ovarian cancer treatment.
Keywords :
Aloesin , Ovarian Cancer , SKOV3 Cells , mitogen-activated protein kinase (MAPK)
