Author/Authors :
Marciniak, Sebastian Department of Pharmacology - Medical University, Lublin, Poland , Wnorowski, Artur Department of Biopharmacy - Medical University, Lublin, Poland , Smolińska, Katarzyna Department of Surgery and Surgical Nursing - Medical University, Lublin, Poland , Walczyna, Beata Department of Clinical Pathomorphology - Medical University, Lublin, Poland , Turski, Waldemar Department of Experimental and Clinical Pharmacology - Medical University, Lublin, Poland , Kocki, Tomasz Department of Experimental and Clinical Pharmacology - Medical University, Lublin, Poland , Paluszkiewicz, Piotr Department of Surgery and Surgical Nursing - Medical University, Lublin, Poland , Parada-Turska, Jolanta Department of Rheumatology and Connective Tissue Diseases - Medical University, Lublin, Poland
Abstract :
Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA), a tryptophan metabolite formedalong the kynurenine metabolic pathway, possesses anti-inflammatory and antioxidant properties. Its presence in food and itspotential role in the digestive system was recently reported. The aim of this study was to define the effect of KYNA on liverfailure. The Wistar rat model of thioacetamide-induced liver injury was used. Morphological and biochemical analyses as well asthe measurement of KYNA content in liver and hepatoprotective herbal remedies were conducted. The significant attenuationof morphological disturbances and aspartate and alanine transaminase activities, decrease of myeloperoxidase and tumornecrosis factor-α, and elevation of interleukin-10 levels indicating the protective effect of KYNA in thioacetamide (TAA) -induced liver injury were discovered. In conclusion, the hepatoprotective role of KYNA in an animal model of liver failure wasdocumented and the use of KYNA in the treatment of ALF was suggested.
Keywords :
Kynurenic Acid , Thioacetamide-Induced , Liver Injury , Acute liver failure (ALF
