Clinical Characteristics and Prognosis of GastrointestinalMetastases in Solid Tumor Patients: A Retrospective Study andReview of Literatures

Background. According to the literature and our experience, patients with gastrointestinal metastases are relatively rare. Numerouscase reports and literature reviews have been reported. We present one of the larger case series of gastrointestinal metastases.Objectives. To explore the clinical characteristics and prognosis of patients with gastrointestinal tract metastases, which are raremetastatic sites.Methods. Patients with gastrointestinal metastases in the setting of stage IV primary carcinomas treated at BeijingDitan Hospital and Peking University International Hospital from November 1992 to August 2017 were included in this study. Thediagnosis of gastrointestinal tract metastases was based on histopathology.Results.30patients(medianage56years,56.7%female)were included. The most common primary carcinomas associated withgastrointestinal metastases were breast (11 patients, 36.7%),stomach (9 patients, 30.0%), and lung (4 patients, 13.3%) cancer. The major pathological types were adenocarcinoma (16 patients,53.3%) and ductal carcinoma (9 patients, 30.0%). Ten patients (33.3%) underwent local gastrointestinal treatment, and 20 patients(66.7%) underwent nonlocal treatment (involving chemotherapy alone or best supportive care). For breast cancer patients and gastriccancer patients who underwent local therapy, a significant survival advantage was observed (p=0:001andp=0:012,respectively).The presence of other common metastases was identified as an independent poor prognostic factor through multivariate analysiswith a HR (hazard ratio) of survival of 0.182 (95% confidence interval (CI) 0.11-0.523,p=0:031).Conclusion. Gastrointestinalmetastases are most frequently from breast invasive ductal carcinoma. The presentation of other common metastases withgastrointestinal metastasis indicates poorprognosis,andselectedpatientsmaybenefit from surgical intervention.